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REM and stage 3, 4 sleep aredecreased; REM-NREM sleep cycle is disrupted.The effects on sleep become progressively lessmarked if the drug is taken every nightconsecutively. Evidence-based practice:Barriers and facilitators for speech-language pathologists. Advances in trauma, vascular, spinal, oncologic, and functional neurosurgeryhave all been made as a direct result of highly controlled and well-designed clinicalstudies. The degradation product of only one drug(tetracycline) has caused toxicity in man.
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